Louis Schwartz

Release Kinetics of Ibuprofen from Swellable Organically Modified Silica by Means of a Non-Active Release Modulator

April 5, 2021   /  

Student Name: Louis Schwartz
Major(s): Chemistry
Minor(s): Theatre
Advisor(s): Dr. Paul L. Edmiston (advisor); Dr. Sarah Sobeck (2nd reader)

Controlled drug release is something that is important in the medical field. One approach to control drug delivery is to entrap the drug in something else (usually a capsule). The goal of this project is to develop a controlled release system based on encapsulants for ibuprofen (IBP). Swellable organically modified silica (SOMS) was used to co-encapsulate IBP with non-active poly-alcohol release modulates were used. When the poly-ethylene glycol (MW = 8,000)used as the non-active release modulate, the rate of release of IBP from SOMS is equal to the rate of release for free IBP in deionized water. When the longest chain length modulator was used 1.93 mg of IBP was released after one week, in the same time span with free IBP in deionized water, 1.47 mg were released. The higher the molecular weight of the non-active release modulates (Polyethylene Glycols [PEGs], in this case), the faster the release rate of IBP from SOMS. The release of ibuprofen rom SOMS into a continuous flow stream of deionized water is as fast or faster than that of the dissolution rate of free ibuprofen in a continuous flow stream of deionized water. The rate of release of ibuprofen increases with higher molecular weight poly-alcohol materials. The data also suggest that the release rate of ibuprofen from SOMS can be controlled by altering the molecular weight of the modulator and by the amount of the modulator that is loaded into SOMS.

Louis will be online to field comments on April 16: 10am-noon EDT (Asia: late evening, PST 6am-8am, Africa/Europe: late afternoon).

40 thoughts on “Release Kinetics of Ibuprofen from Swellable Organically Modified Silica by Means of a Non-Active Release Modulator”

  1. Thanks for the well-organized presentation of an interesting project (and the shout-out). The interior of SOMS is highly hydrophobic, yet polar compounds like PEG and glycerol appear to remain behind while ibuprofen gets released. Why do you think that is, and what method(s) could you use to determine if the modulators are staying behind?

    1. Hi Dr. Bonvallet, great to hear from you! Not exactly sure why it’s happening at the moment, just know that it’s happening right now, for some reason they’re also sticking around there could be an interaction with the ibuprofen and modulator (not very likely), could be an interaction between the SOMS and the modulators (more likely). And the way to test this would be with IR as all of my modulators will absorb with IR (this is just going to tell me if they’re left behind, not really the quantity that remains behind, though).

  2. Well done Lewis! It was a nice discovery that polymer chain length can control release rate. This will be very handy controlling the release of the active ingredients.

    1. Thanks, Dr. E, it’s been great working with you this past year and a half in these crazy pandemic times!

  3. Great job! Really nice presentation, and I was able to follow quite a bit of it (which is great for someone who hasn’t had a science course in 5 years). I do have a few general questions:

    Would constant release of the IBP be dangerous if ingested? Or would the amount still be regulated?

    How would constant release of Ibuprofen benefit those who use it?

    1. Hi Taylor,
      First off constant release would not be dangerous in this model as I am using very small concentrations of the drug at the moment a ug (microgram) is 1×10^-3 mg of the drug so not very much is releasing at those set intervals or overall in general. The steady release would give a constant dosage at each hour overtime. Also the next step of this would be to test in a transdermal form, like a patch, SOMS have not been approved as safe by the FDA as an ingestible ingredient.

      The constant release doesn’t just have to be of ibuprofen, you could definitely test this with countless other drugs (nicotine being the main example) so a constant release would give the same dosage every hour for the specific time allotted and make for taking less of it in the span of (in the case of ibuprofen) 4-6 hours.

      I hope that answers that let me know if you need any clarification

  4. What a fascinating project! Great job Louis. Your presentation was very well organized. Thank you for sharing your research!

  5. Congratulations Louis! I have enjoyed seeing your growth as a student over your time at Wooster and hearing about your IS project. How has this experience in research shaped the type of work you hope to do in the future?

    1. Thank you, Dr. Sobeck. To be completely honest I honestly don’t know what I want to do in the future at this point in time. Before coming into senior year, I had my mind set on being an analytic chemist but after taking inorganic, I love the metal synthesis and the concepts involved there, so I want to try to find the cross roads there and if that involves some kinetic chemistry or medicinal chemistry, great, if not, I still have my mind open to all possibilities down the road.

  6. Thanks for sharing your project, Louis! If you could go back and share some perspective with your Junior IS or fall self, what would it be?

    1. Hi Dr. Morris,
      My perspective would definitely be to not procrastinate on the writing aspect of IS. I finished my lab work in the fall semester early and did not start writing till the beginning of the second semester, had I started writing earlier or even during winter break, I don’t think I wouldn’t have been as bogged down by the writing this semester. I would also pass the advice on to students in Junior IS this year too. Don’t procrastinate on writing, while the lab work is more fun, communicating results and process is JUST AS IMPORTANT!

  7. Louis!! I don’t have a question because chemistry is completely beyond my comprehension, but I wanted to give you my congratulations! I’m so proud :,)

    1. Thank you Cara! It’s been awesome working with on the QSU board this year and getting to know you these past 3 years! (I think that’s who this is)

  8. Hey Louis, nice job on your I.S. and presentation. I just wanted to ask, do you have an idea as to what causes the SOMS with the large molecular weight modulator releases almost all of the ibuprofen after a week while the free ibuprofen doesn’t see the same kind of release?

    1. Hi Elliot,
      I have a general idea but not something complete for you so I’ll try to describe it the best I can. The PEGs/glycerol (although, as seen in the data, glycerol isn’t the best) act as a scaffolding/doorstop of sorts to hold the pores of the SOMS open. Not really sure why all the ibuprofen is not dissolving, it has a much higher dissolution rate in ethanol, we know that from previous data but not really sure as to why it’s not releasing as much in just water. It’s an interesting finding that would definitely need to be looked into in future research. But I don’t know why this phenomenon is happening.

  9. Congratulations, Louis!! Shaker proud 🙂 I hope you have a great rest of your semester!

    1. Thanks Olivia, it’s been a pleasure to go through these last 8 years of schooling together with you! Go Raiders!

    1. Thank you, as seen in this a lot of this is preliminary, but the findings will definitely help to guide future research.

  10. Great job! I’ve enjoyed listening to your presentation! And I have a general question:

    What enzyme does ibuprofen inhibit?

  11. Congratulations on completing IS! Very nice presentation simplifying the information for those of us who are less STEM-oriented. Thank you for sharing!

  12. Fantastic, just impecable.
    P.s I dont understand anyting but it sounds very smart.

    1. Thank you, Dr. Feierabend, it’s been a pleasure working with you this semester in PChem!

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